Researchers in Sheffield Hallam University’s School of Biosciences and Chemistry funded by Cancer Research UK are developing what is being described as a “fingerprint” in breath - identifying specific molecular signatures that could signal the presence of cancer before traditional symptoms appear.
The findings could also potentially revolutionise early detection methods for other inflammation-linked cancers, including laryngeal and ovarian cancer.
As obtaining breath is non-invasive, people could be checked regularly and cancers detected at an earlier stage. And earlier detection may increase the number of treatment options and ultimately save lives.
Mesothelioma is a cancer that usually starts in the layers of tissue that cover each lung. Most people diagnosed with the disease already have an advanced stage of cancer and an invasive biopsy is usually needed.
Every year around 230 people are diagnosed with mesothelioma cancer in Yorkshire and the Humber.
Dr Sarah Haywood-Small, Associate Head of School in Biosciences and Chemistry at Sheffield Hallam University, said: “The results from this study present an encouraging step forward in how we detect and monitor mesothelioma and other asbestos-related diseases. While more research is needed, these initial findings suggest we’re on track to develop a more effective diagnostic approach.
"The human breath contains valuable biological information—offering a window into our body’s metabolism. By learning to read these signals, we can detect diseases earlier, monitor conditions more accurately, and potentially save lives through more timely interventions.
“By understanding the relationship between breath compounds and cancer metabolism, we are working toward a future where cancer detection could be as simple as breathing into a device, offering a non-invasive and early diagnostic tool.”
Dr Catherine Elliott, director of research and partnerships at Cancer Research UK, said: “It’s encouraging to see any progress being made into the diagnosis of mesothelioma which can be such a challenging cancer to treat.
“Sadly, every year around 2,300 people are diagnosed with mesothelioma in England, which is more than 6 individuals every day facing a very difficult future.
“We look forward to seeing the development of the breath test in Sheffield and the next steps for this innovative approach.”
The team of researchers hope that the breath test could eventually be rolled out as part of Health and Safety checks on anyone who has worked in industries traditionally linked to asbestos exposure.
Cancer Research UK has invested £70,657 into the research.
Sue Harrison faced a mesothelioma diagnosis in 2023. The 73-year-old had been treated for lymphoma, but a lesion on her lung had not shrunk during chemotherapy and further tests confirmed she had mesothelioma.
The mum-of-three was initially told she would have between 12 and 18 months to live. But she remains determined to stay positive and is marking off special holidays from her bucket list.
Sue, who lives in Gleadless Valley, could have been living with the disease for as long as 30 years. She remains unsure how she could have been exposed to asbestos but used to wash her former husband’s dirty overalls weekly for 25 years. Sue’s former husband worked in the haulage industry and it’s likely he was exposed to asbestos.
Sue said: “I refuse to allow mesothelioma to take over my life. I want to enjoy what time I have and visit as many exciting places as I can from my bucket list.
“The diagnosis was a total shock, but I am living with it the best I can. I welcome any form of research into mesothelioma as it remains such a horrible disease.”
