Susan Campbell

About

I was awarded my BA (Mod) in Microbiology from Trinity College Dublin, Ireland. I continued my studies at Trinity College and completed a PhD entitled 'The regulation of 3' end processing under the supervision of Prof Ursula Bond. I continued with Prof Bond as a research associate investigating the adaptation of yeast brewing stress to high wort environments before moving initially to UMIST and then to The University of Manchester, where I carried out postdoctoral research on the impact of environmental stress on translation initiation in yeast, in the lab of Dr Mark Ashe.

In 2013 I took up the position of Senior Lecturer at Sheffield Hallam University, my research focusses on how the localisation of proteins within cells impacts upon their function. It is becoming increasingly evident that compartmentalisation of the cytoplasm of cells into discrete regions, enables efficient control of translation initiation. Understanding the regulation of this localisation is a key theme within my research. In particular, I am interested in how the localisation of translation initiation factors within a cell impact upon their function and how this may be important in addressing the molecular mechanisms behind diseases classically associated with translational deregulation. In particular, the neurodegenerative disease childhood ataxia with central nervous system hypomyelination (CACH) or leukoencephalopathy with vanishing white matter (VWM) has been linked to mutations in the translation initiation complex eIF2B and the molecular mechanisms behind how these mutations may impact upon these complexes of eIF2B is a key question within my research.

Currently, I teach across several different modules including; Level 5 modules such as Advanced Cell Biology, Genes to Proteins and Immunology and Microbiology, the Level 6 module Applied Biochemistry and Level 7 modules such as Molecular and Cell Biology and Fundamentals of Microbial Biotechnology. Within these modules I teach topics ranging from general protein synthesis and control to advanced microscopy techniques. I also teach more broadly within the College where I deliver anatomy and physiology lectures to nursing students. I also support final year research projects, masters research projects, MSci, MRes and PhD Students.

I am the Postgraduate Research Tutor for the Biomolecular Sciences Research Centre.

Teaching

Department of Biosciences and Chemistry

College of Health, Wellbeing and Life Sciences

I am a founding member of the BMRC Education and Outreach Research group, and I regularly attend and present at educational conferences to showcase my innovative teaching practises. In 2019, I attended the Educational Biosummit in UCL and presented work I have carried out to integrate science communication into the curriculum. I have been involved in the publication of educational research.

Funded education projects:
Study skills for scientists - are students prepared for the transition to science degrees?- Enhancement of Teaching, Learning & Student Experience – Educational Research Project Funding Dr Susan Campbell and Dr Kathy Rawlinson

Professional and Scientific Practice labs and skills

Essential Biosciences, Advanced Cell Biology, Immunology and Microbiology

BSc Biochemistry, BSc Biology, BSc Human Biology, BSc Biomedical Science
MSc Molecular Microbiology, MSc Cancer Biology
MSci,
MRes,
MPhil,
PhD

Level 4: Cellular Biology and Biochemistry with Microbiology, Professional and Scientific Practice
Level 5: Advanced Cell Biology, Immunology and Microbiology, Genes to Proteins: Biochemistry in Action
Level 6: Applied Biochemistry
Level 7: Fundamentals of Microbial Biotechnology, Cell and Molecular Biology, Case studies in Infectious Disease

Research

The focus of my research is to understand the mechanisms underlying how cells control protein synthesis during stress and disease. Cells can overcome stress by activating stress-responsive signalling pathways such as the ‘integrated stress response’ (ISR) and my lab is interested in understanding the molecular mechanisms underpinning this signalling cascade.

The critical signalling event in the ISR is the phosphorylation of eukaryotic translation initiation factor, eIF2α, by one of four eIF2α kinases. eIF2 phosphorylation controls protein synthesis via inhibiting the activity of a partner complex, eIF2B. When eIF2 is phosphorylated, protein synthesis is downregulated. This allows cells to conserve energy and through downstream effects, cells can either respond to and restore proteostasis or induce apoptosis and die. This makes the ISR critical for maintaining cellular homeostasis.

Recently, the ISR has been implicated as a major pathogenic mechanism in neurodegenerative diseases affecting both children and adults and more recently has even been associated with the cognitive decline associated with normal aging.

In cells, although eIF2B is a ubiquitously expressed protein complex made up of 5 subunits, our lab has identified that it displays specific cellular localisation patterns. Recent work from the Campbell/Allen lab group has revealed that these localisation patterns correspond to subcomplexes of eIF2B containing varied amounts of the 5 subunits. Further work has demonstrated that these subcomplexes show differential responses to the ISR.

We are particularly interested in understanding how this localisation impacts diseases such as Leukoencephalopathy with Vanishing white matter (VWM) which is linked to mutations in subunits of eIF2B. Currently, over 150 missense mutations in eIF2B have been identified however the mechanism of eIF2B involvement in the pathogenesis of this disease remains elusive. Although eIF2B is a global regulator of protein synthesis, the phenotypic effect of the mutations is only observed in oligodendrocytes and astrocytes within the brain.

In collaboration with Dr Liz Allen, we have identified eIF2B bodies in cells linked to the pathology of VWM. Using a GFP tagged eIF2Bε subunit, live cell imaging studies suggest that eIF2B bodies are present within human glial cells. We are currently investigating the functional importance of these eIF2B bodies with respect to translational control and VWM disease. This work is currently funded by a grant from Great Ormond Street Hospital and Sparks.

My research focusses on the control of translation initiation in response to stress conditions in the budding yeast Saccharomyces cerevisiae. During translation initiation the Met-tRNAi is recruited to the 40S ribosomal subunit in a ternary complex with eIF2-GTP. On identification of an AUG codon the eIF2-GTP is hydrolysed releasing eIF2-GDP from the complex. One of the key regulatory steps in the translation initiation pathway involves the recycling of inactive GDP-bound eIF2 into active GTP-bound eIF2. This step is catalysed by the guanine nucleotide exchange factor eIF2B. Stresses such as nutritional starvation directly target this exchange factor by activation of a kinase, which phosphorylates the alpha subunit of the G protein eIF2. This phosphorylation inhibits the exchange activity of eIF2B thereby down-regulating translation initiation.

Localisation of translation initiation factors

We are interested in how the localisation of factors involved in the translation initiation pathway impact upon the control of translation initiation. We have identified that both eIF2B and eIF2, localise to a cytoplasmic body termed ‘the eIF2B body’. Evidence from live cell imaging techniques such as FRAP (fluorescent recovery after photobleaching) suggest that eIF2 shuttles between the cytoplasm and these bodies and that this rate of shuttling alters in response to stresses which directly target the eIF2B exchange reaction.
Therefore these eIF2B bodies may be sites where eIF2B catalyses the exchange of inactive eIF2xGDP for active eIF2xGTP and therefore form centres within the cells for the regulation of translation initiation. Future studies will aim to determine the precise function, structure and requirement for the eIF2B body within yeast cells.

eIF2B mutations and human genetic diseases

The neurological disorder Leukoencephalopathy with Vanishing white matter (VWM) has been linked to mutations in these subunits of eIF2B. Currently, over 150 missense mutations in eIF2B have been identified however the mechanism of eIF2B involvement in the pathogenesis of this disease remains elusive. Although eIF2B is a global regulator of protein synthesis, the phenotypic effect of the mutations is only observed in oligodendrocytes and astrocytes within the brain.

We have identified eIF2B bodies in mammalian cells and more specifically in cells linked to the pathology of VWM. Using a GFP tagged eIF2Bε subunit, live cell imaging studies suggest that eIF2B bodies are present within human glial cells. The distribution of eIF2B bodies in these cells reveals heterogeneous populations differing in size and abundance. We are currently investigating the functional importance of these eIF2B bodies with respect to translational control and VWM disease.

Current funded projects:
eIF2B bodies in association with the human disease Leukoencephalopathy with Vanishing White Matter-a novel diagnostic tool. May 2019-2022, funded by GOSH/Sparks

Current collaborators:
Dr Elizabeth K. Allen, BMRC
Dr Prachi Stafford, BMRC
Dr Simon Turega, BMRC
Dr David Smith, BMRC
Dr Truus Abbink, VMU, The Netherlands
Dr Paul Clarke, ICR
Clinical collaborators: Dr Santosh Mordekar, Sheffield Children's Hospital

Publications

Journal articles

Bookey, N., Drago, P., Leung, K.-.Y., Hughes, L., MacCooey, A., Ozaki, M., ... Parle-McDermott, A. (2024). The differential translation capabilities of the human DHFR2 gene indicates a developmental and tissue specific endogenous protein of low abundance. Molecular & cellular proteomics : MCP, 23 (3). http://doi.org/10.1016/j.mcpro.2024.100718

Millar, J., Campbell, S., Duckett, C., Doyle, S., & Cole, L. (2023). MALDI and Trace Metal Analysis in Age-Related Macular Degeneration. Methods in molecular biology (Clifton, N.J.), 2688 (2688), 1-13. http://doi.org/10.1007/978-1-0716-3319-9_1

Millar, J., Gibbons, L., Costa, C., Schneider, E., von Gerichten, J., Bailey, M.J., ... Cole, L. (2023). Multimodal imaging of metals in a retinal degeneration model to inform on ocular disease. Analytica, 4 (3), 264-279. http://doi.org/10.3390/analytica4030021

Knowles, A.A., Campbell, S.G., Cross, N.A., & Stafford, P. (2023). Dysregulation of Stress-Induced Translational Control by Porphyromonas gingivalis in Host Cells. Microorganisms, 11 (3). http://doi.org/10.3390/microorganisms11030606

Millar, J., Ozaki, E., Campbell, S., Duckett, C., Doyle, S., & Cole, L. (2022). Multiomic Mass Spectrometry Imaging to Advance Future Pathological Understanding of Ocular Disease. Metabolites, 12 (12). http://doi.org/10.3390/metabo12121239

Shippey, L.E., Campbell, S.G., Hill, A.F., & Smith, D.P. (2022). Propagation of Parkinson's disease by extracellular vesicle production and secretion. Biochemical Society Transactions. http://doi.org/10.1042/bst20220204

Hanson, F., Hodgson, R.E., Ribeiro de Oliveira, M.I., Allen, E., & Campbell, S. (2022). Regulation and function of elF2B in neurological and metabolic disorders. Bioscience Reports, 42 (6). http://doi.org/10.1042/BSR20211699

Knowles, A., Campbell, S., Cross, N., & Stafford, P. (2021). Bacterial manipulation of the Integrated Stress Response: a new perspective on infection. Frontiers in Microbiology, 12. http://doi.org/10.3389/fmicb.2021.645161

Norris, K., Hodgson, R., Dornelles, T., Allen, K.E., Abell, B., Ashe, M.P., & Campbell, S.G. (2020). Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease. Journal of Biological Chemistry. http://doi.org/10.1074/jbc.RA120.014956

Lacey, M.M., Campbell, S.G., Shaw, H., & Smith, D. (2020). Self-selecting peer groups formed within the laboratory environment have a lasting effect on individual student attainment and working practices. FEBS Open Bio. http://doi.org/10.1002/2211-5463.12902

Hodgson, R.E., Varanda, B.A., Ashe, M.P., Allen, K.E., & Campbell, S. (2019). Cellular eIF2B subunit localisation: implications for the integrated stress response and its control by small molecule drugs. Molecular biology of the cell, 30 (8), 933-1049. http://doi.org/10.1091/mbc.E18-08-0538

Greene, C., Kealy, J., Humphries, M.M., Gong, Y., Hou, J., Hudson, N., ... Campbell, M. (2017). Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia. Molecular psychiatry, 3 (11), 2156-2166. http://doi.org/10.1038/mp.2017.156

Lui, J., Castelli, L.M., Pizzinga, M., Simpson, C.E., Hoyle, N.P., Bailey, K.L., ... Ashe, M.P. (2014). Granules harboring translationally active mRNAs provide a platform for P-Body formation following stress. Cell Reports, 9 (3), 944-954. http://doi.org/10.1016/j.celrep.2014.09.040

Castelli, L.M., Lui, J., Campbell, S., Rowe, W., Zeef, L.A., Holmes, L.E., ... Ashe, M.P. (2011). Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S pre-initiation complex accumulation, while the pentose phosphate pathway is co-ordinately up-regulated. Molecular Biology Of The Cell, 22 (18), 3379-3393. http://doi.org/10.1091/mbc.E11-02-0153

Singh, C.R., Watanabe, R., Zhou, D., Jennings, M.D., Fukao, A., Lee, B., ... Asano, K. (2011). Mechanisms of translational regulation by a human eIF5-mimic protein. Nucleic Acids Research, 39 (19), 8314-8328. http://doi.org/10.1093/nar/gkr339

Singh, C.R., Watanabe, R., Zhou, D., Jennings, M.D., Fukao, A., Lee, B., ... Asano, K. (2011). Mechanisms of translational regulation by a human eIF5-mimic protein. Nucleic acids research, 39 (19), 8314-8328.

Taylor, E.J., Campbell, S., Griffiths, C.D., Reid, P.J., Slaven, J.W., Harrison, R.J., ... Ashe, M.P. (2010). Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body. Molecular Biology Of The Cell, 21 (13), 2202-2216. http://doi.org/10.1091/mbc.E09-11-0962

Lui, J., Campbell, S., & Ashe, M.P. (2010). Inhibition of translation initiation following gucose depletion in yeast facilitates a arationalization of mRNA content. Biochemical Society Transactions, 38 (4), 1131-1136. http://doi.org/10.1042/BST0381131

Miles, W.O., Jaffray, E., Campbell, S., Takeda, S., Bayston, L.J., Basu, S.P., ... Ashe, H.L. (2008). Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo. Genes and Development, 22 (18), 2578-2590. http://doi.org/10.1101/gad.494808

James, T.C., Usher, J., Campbell, S., & Bond, U. (2008). Lager yeasts possess dynamic genomes that undergo rearrangements and gene amplification in response to stress. Current genetics, 53 (3), 139-152. http://doi.org/10.1007/s00294-007-0172-8

(2008). A Sequence Element Downstream of the Yeast HTB1 Gene Contributes to mRNA 3′ Processing and Cell Cycle Regulation. Molecular and Cellular Biology, 28 (5), 1873. http://doi.org/10.1128/mcb.02229-07

Hoyle, N.P., Castelli, L.M., Campbell, S., Holmes, L.E.A., & Ashe, M.P. (2007). Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies. Journal of Cell Biology, 179 (1), 65-74. http://doi.org/10.1083/jcb.200707010

Rohde, J.R., Campbell, S., Zurita-Martinez, S.A., Cutler, N.S., Ashe, M., & Cardenas, M.E. (2004). TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. Molecular and cellular biology, 24 (19), 8332-8341. http://doi.org/10.1128/MCB.24.19.8332-8341.2004

Holmes, L.E.A., Campbell, S., De Long, S.K., Sachs, A.B., & Ashe, M.P. (2004). Loss of translational control in yeast compromised for the major mRNA decay pathway. Molecular and cellular biology, 24 (7), 2998-3010. http://doi.org/10.1128/MCB.24.7.2998-3010.2004

James, T.C., Campbell, S., Donnelly, D., & Bond, U. (2003). Transcription profile of brewery yeast under fermentation conditions. Journal of applied microbiology, 94 (3), 432-48. http://doi.org/10.1046/j.1365-2672.2003.01849.x

Campbell, S., Li Del Olmo, M., Beglan, P., & Bond, U. (2002). A sequence element downstream of the yeast HTB1 gene contributes to mRNA 3' processing and cell cycle regulation. Molecular and cellular biology, 22 (24), 8415-8425. http://doi.org/10.1128/MCB.22.24.8415-8425.2002

James, T.C., Campbell, S.G., & Bond, U.M. (2002). Comparative analysis of global gene expression in lager and laboratory yeast strains grown in wort. Proceedings of the IEEE, 90 (12), 1887-1899. http://doi.org/10.1109/jproc.2002.805300

Bond, U., Campbell, S.G., & James, T.C. (2001). A model organism for genomic and postgenomic studies. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society, 20 (4), 22-32. http://doi.org/10.1109/51.940040

Conference papers

Millar, J., Campbell, S., Duckett, C., Doyle, S.L., & Cole, L. (2022). Multimodal mass spectrometry imaging of key biomarkers to study age-related macular degeneration [Abstract only]. Investigative ophthalmology & visual science, 63 (7), 471. https://iovs.arvojournals.org/article.aspx?articleid=2778965

Book chapters

Campbell, S.G., & Ashe, M.P. (2007). An approach to studying the localization and dynamics of eukaryotic translation factors in live yeast cells. (pp. 33-45). http://doi.org/10.1016/s0076-6879(07)31003-3

Theses / Dissertations

Oliveira, M.I.R.D. (2023). The role of eIF2Bα in the integrity of eIF2B bodies. (Doctoral thesis). Supervised by Allen, L., & Campbell, S. http://doi.org/10.7190/shu-thesis-00568

Hanson, F. (2023). The Role of eIF2B Localisation in Cell-specific Stress Responses. (Doctoral thesis). Supervised by Campbell, S. http://doi.org/10.7190/shu-thesis-00555

Knowles, A.A. (2023). Crosstalk between host stress-induced translational controland infection by Porphyromonas gingivalis. (Doctoral thesis). Supervised by Stafford, P., Campbell, S., & Cross, N. http://doi.org/10.7190/shu-thesis-00535

Hodgson, R.E. (2019). eIF2B bodies and their role in the integrated stress response. (Doctoral thesis). Supervised by Campbell, S. http://doi.org/10.7190/shu-thesis-00240

Norris, K.F. (2018). eIF2B Bodies and their Role in the Control ofProtein Synthesis. (Doctoral thesis). Supervised by Campbell, S. http://doi.org/10.7190/shu-thesis-00129

Media

Campbell, S., & Allen, E. (2019). Tackling a rare brain disease that affects children. [Video].

Presentations

Campbell, S. (2022). The impact of VWMD mutations on eIF2B localisation: A novel insight into VWMD pathology and potential therapeutic treatment. Presented at: Leukolabs Inaugural Meeting, University of Sheffield

Hanson, F., Cross, A., Allen, K.E., & Campbell, S. (2022). A cell type specific role for eIF2B localisation in controlling cellular response to acute and chronic stress. Presented at: Translation UK, Sheffield Hallam University

Campbell, S. (2022). eIF2B bodies: regulators of translation in cells. Presented at: Seminar series, Nottingham Trent University

Campbell, S., Knowles, A., Cross, N., & Stafford, P. (2022). Porphyromonas gingivalis gingipains modulate host translational control during oxidative stress. Presented at: Microbiology Society annual conference, Belfast

Knowles, A., Campbell, S., Cross, N., & Stafford, P. (2021). Characterising the role of the Integrated Stress Response in the pathomechanism of the periodontopathogen Porphyromonas gingivalis. Presented at: European oral microbiology workshop, Online conference

Knowles, A., Campbell, S., Cross, N., & Stafford, P. (2021). Characterising the role of the Integrated Stress Response in the pathomechanism of the periodontopathogen Porphyromonas gingivalis. Presented at: Oral microbiology and immunology group workshop, Virtual conference

Campbell, S. (2019). eIF2B bodies as a diagnostic tool for Leukoencephalopathy with Vanishing White Matter. Presented at: Translational Research in Paediatric Rare Diseases Symposium, Wellcome Trust Conference Centre, London

Campbell, S., & Rawlinson, K. (2019). Integrating Public Engagement and Outreach into the Science Curriculum. Presented at: Bioscience Education Summit, UCL, London

Campbell, S. (2019). The control of protein synthesis in stress and disease.

Hodgson, R., Campbell, S., & Allen, K. (2018). eIF2B subunits localise to distinct populations of eIF2B bodies that allow for differential regulation by the ISR. Presented at: Translation UK, The University of Manchester

Lacey, M., Smith, D., & Campbell, S. (2018). How peer / friendship groups form, and their effect on engagement and attainment. Presented at: Annual Learning and Teaching Conference, Sheffield Hallam University

Campbell, S. (2017). eIF2B bodies: regulators of translation in cells. Presented at: Gene Regulation Seminar Series, The University of Manchester

Campbell, S. (2017). Alternative routes to Independence. Presented at: Athena Swan Seminar Series, The Babraham Institute, Campbridge

Hodgson, R., Allen, K., & Campbell, S. (2016). eIF2B subcomplexes in cells linked to Vanishing White Matter Disease pathology. Presented at: Sheffield Glial Symposium, Sheffield Hallam University

Campbell, S. (2016). eIF2B bodies: their role in the control of translation and leukoencephalopathy with vanishing white matter.

Campbell, S., Hoyle, N., Griffiths, C., & Ashe, M. (2005). Discrete cytoplasmic foci represent sites of eIF2 and eIF2B localisation in the yeast Saccharoymces cerevisiae. Presented at: Translation UK, The University of Glasgow

Campbell, S. (2005). eIF2B bodies and their role in translation initiation. Presented at: Translation UK, University of Glasgow

Campbell, S., & Ashe, M. (2005). Discrete cytoplasmic foci represent sites of eIF2 and eIF2B localisation in the yeast Saccharomyces cerevisiae. Presented at: British Yeast Group Meeting

Posters

Garrard, K., Campbell, S., & Allen, K.E. (2023). Paediatric ataxia and cell stress:The role of the unfolded protein response in paediatric ataxia. Presented at: Annual meeting of the British Paediatric Neurology Association, Edinburgh

Garrard, K., Campbell, S., & Allen, K.E. (2022). The role of the unfolded protein response (UPR) in childhood genetic ataxia. Presented at: Leukolabs, The University of Sheffield

Campbell, S., Oliveira, M., Cross, A., & Allen, K.E. (2022). The role of eIF2Bɑ in the integrity of eIF2B bodies in glial and neuronal cells. Presented at: Translational Control, Cold Spring Harbor Laboratories

Hanson, F., Allen, K.E., Cross, A., & Campbell, S. (2022). eIF2B localisation is regulated in a cell type specific manner during acute and chronic activity of the integrated stress response. Presented at: Translational Control, Cold Spring Harbor Laboratories

Oliveira, M., Campbell, S., Cross, A., & Allen, K.E. (2022). The role of eIF2Bɑ in the integrity of eIF2B bodies in glial and neuronal cells. Presented at: Translation UK, Sheffield Hallam University

Hodgson, R., Allen, K.E., & Campbell, S. (2022). The functional localisation of eIF2B: insight into pathophysiology of VWM disease. Presented at: Translation UK, Sheffield Hallam University

Knowles, A., Campbell, S., Cross, N., & Stafford, P. (2022). Characterising the role of the Integrated Stress Response in the pathomechanism of the periodontopathogen Porphyromonas gingivalis. Presented at: Translation UK, Sheffield Hallam University

Handley, J., Cole, L., Allen, K.E., & Campbell, S. (2022). Mass spectrometry analysis of eIF2B bodies during stress and disease. Presented at: Translation UK, Sheffield Hallam University

Campbell, S., Hanson, F., Cross, A., Allen, K.E., & Campbell, S. (2021). Differential eIF2B-mediated translation control in neuronal and glial cells. Presented at: Protein Synthesis and Translational Control, Virtual EMBL conference

Campbell, S., Oliveira, M., & Allen, K.E. (2021). B-cell epitope prediction and Immunocytochemistry methodology for eIF2B detection in neuronal and glial cells. Presented at: Protein Synthesis and Translational Control, Virtual EMBL conference

Hodgson, R., Allen, K.E., & Campbell, S. (2021). VWM mutations can disrupt the localisation of eIF2B: A diagnostic tool for VWM? Presented at: Protein Synthesis and Translational Control, Virtual EMBL conference

Campbell, S., Knowles, A., & Stafford, P. (2021). Characterising the role of the Integrated Stress Response in the pathomechanism of the periodontopathogen Porphyromonas gingivalis. Presented at: Protein Synthesis and Translational Control, Virtual EMBL conference

Hodgson, R., Allen, K.E., & Campbell, S. (2021). VWM mutations can disrupt the localisation of eIF2B: A diagnostic tool for VWM? Presented at: Translation UK, Virtual conference

Hanson, F., Cross, A., Allen, K.E., & Campbell, S. (2021). Differential eIF2B-mediated translation control in neuronal and glial cells. Presented at: Translation UK, Virtual conference

Knowles, A., Campbell, S., & Stafford, P. (2021). Characterising the role of the Integrated Stress Response in the pathomechanism of the periodontopathogen Porphyromonas gingivalis. Presented at: Translation Uk, Virtual conference

Garrard, K., Allen, K., Campbell, S., Beauchamp, N., Panayi, M., & Mordekar, S. (2021). Genetic Diagnostic Rates in Paediatric Ataxia. Presented at: 47th Annual meeting of the British Paediatric Neurology Association, virtual

Knowles, A., Campbell, S., & Stafford, P. (2020). Characterising the role of the ISR in the pathomechanism of the Periodontopathogen Porphyromonas gingivalis. Presented at: Translational Control (Virtual), Cold Spring Harbor Laboratories, Long Island, USA

Campbell, S., Allen, K., & Hodgson, R. (2020). eIF2B bodies―Implications for the ISR and disease phenotypes. Presented at: Translational Control (Virtual), Cold Spring Harbor Laboratories

Hanson, F., Cross, A., Allen, K., & Campbell, S. (2020). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: Cold Spring Harbor meeting: Translational Control (Virtual), Cold Spring Harbor Laboratories

Hanson, F., Allen, K., Cross, A., & Campbell, S. (2019). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: XIV European Meeting on Glial Cells in Health and Disease, Porto, Portugal

Hodgson, R., Allen, K., & Campbell, S. (2019). The impact of eIF2B mutations and ISR-modifying drugs on eIF2B localisation. Presented at: XIV European Meeting on Glial Cells in Health and Disease, Porto, Portugal

Hanson, F., Cross, A., Allen, K., & Campbell, S. (2019). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: Translation UK, University of Glasgow

Hodgson, R., Allen, K., Cross, A., & Campbell, S. (2019). The impact of eIF2B mutations and ISR-modifying drugs on eIF2B localisation. Presented at: Translation UK, University of Glasgow

Campbell, S., Norris, K., Abell, B., & Ashe, M. (2018). Investigating the impact of eIF2Bα on eIF2B body localisation. Presented at: Translational Control, Cold Spring Harbor Laboratories, New York, USA

Hodgson, R., Allen, K., & Campbell, S. (2018). eIF2B subunits localise to distinct populations of eIF2B bodies that allow for differential regulation by the ISR in cells linked to VWM. Presented at: Translational Control, Cold Spring Harbor Laboratories

Hodgson, R., Allen, K., & Campbell, S. (2017). eIF2B subcomplexes display differential control of translation initiation in cells directly affected by VWM. Presented at: Translation UK, University of Nottingham

Norris, K., Abell, B., Ashe, M., & Campbell, S. (2017). The Role of Gcn3 in the formation of eIF2B Bodies. Presented at: Translation UK, The University of Nottingham

Campbell, S., Hodgson, R., Allen, K., & Abreu Varanda, B. (2016). eIF2B SUB COMPLEXES EXIST IN CELLS LINKED TO VWM. Presented at: Translational Control, Cold Spring Harbor Laboratories, Long Island, USA

Norris, K., Abell, B., Ashe, M., & Campbell, S. (2016). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: Translational Control, Cold Spring Harbor Laboratories

Hodgson, R., Allen, K., & Campbell, S. (2016). Characterisation of the Functional Significance of eIF2B Bodies in Leukoencephalopathy with Vanishing White Matter. Presented at: Translation UK, University of Surrey

Norris, K., Abell, B., Ashe, M., & Campbell, S. (2016). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: Translation UK, University of Surrey

Norris, K., Abell, B., Ashe, M., & Campbell, S. (2015). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: Translation UK, University of Aberdeen

Norris, K., Abell, B., Ashe, M., & Campbell, S. (2015). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: British Yeast Group Meeting, The University of Manchester

Campbell, S., & Ashe, M. (2014). eIF2Bα, a key factor in the integrity of eIF2B bodies. Presented at: Translational Control, Cold Spring Harbor Laboratories

Campbell, S., Martins, I., Jacquemet, G., & Ashe, M. (2014). eIF2Ba A KEY FACTOR IN THE INTEGRITY OF eIF2B BODIES. Presented at: British Yeast Group Meeting, The University of Exeter

Campbell, S. (2009). Gcn3 is involved in the formation of eIF2B bodies. Presented at: Translation UK, University of Warick

Campbell, S., Taylor, E., Reid, P., & Ashe, M. (2009). eIF2BA KEY FACTOR IN THE INTEGRITY OF eIF2B BODIES. Presented at: Translation UK, University of Warick

Campbell, S., Hoyle, N., Griffiths, C., & Ashe, M. (2008). Discrete cytoplasmic foci represent sites of eIF2 and eIF2B localisation in the yeast Saccharoymces cerevisiae. Presented at: Translational Control, Cold Spring Harbor Laboratories

Campbell, S., Reid, P., & Ashe, M. (2008). eIF2/eIF2B bodies and their control in translation initiation and cell physiology. Presented at: Translation UK, University of Manchester

Campbell, S., Hoyle, N., Grifffiths, C., & Ashe, M. (2007). Characterisation of eIF2/eIF2B bodies in the yeast Saccharomyces cerevisiae. Presented at: Translation UK, University of Nottingham

Campbell, S. (2007). eIF2B bodies and their role in translation initiation. Presented at: Translation UK, University of Nottingham

Campbell, S. (2006). eIF2B bodies and their control in translation. Presented at: Translation UK, University of Newcastle

Ashe, M., & Campbell, S. (2006). Characterisation of eIF2/eIF2B bodies in the yeast Saccharomyces cerevisiae. Presented at: British Yeast Group Meeting

Campbell, S., & Ashe, M. (2004). Discrete cytoplasmic foci respresent sites of eIF2 and eIF2B localisation in the yeast Saccharomyces cerevisiae. Presented at: Translational Control, Cold Spring Harbor Laboratories

Other activities

Local Ambassador for Biochemical Society (https://www.biochemistry.org/membership/networks/local-ambassadors/) Conference Organisation: • Co-organiser for virtual Translation UK Meeting 2021 (Main sponsor The Biochemical Society). • 2016 to 2019 Co-organiser for Sheffield Glial Symposium (joint research day with University of Sheffield, supported by small meeting grants from The Company of Biologists and The Biochemical Society). Conference Session Chairs: • Translation UK, University of Glasgow (July 2019). • Translation UK, University of Manchester (July 2018). • Translation UK, University of Aberdeen, (July 2015). Journal Reviewing: Regular reviewer for Biochemical Journal and Biosciences Reports

Postgraduate supervision

Current lab members

Post doctoral Researcher: Dr Rachel Hodgson

PhD students:
Joshua Handley, project entitled, 'Mass spectrometry analysis of eIF2B bodies during stress and disease'. Director of studies: Dr Susan Campbell, Supervisors: Dr Laura Cole, Dr Liz Allen.

Joshua Millar, project entitled, 'Mass spectrometry imaging to inform the molecular pathology of Age-related Macular Degeneration'. Director of studies Dr Laura Cole, Supervisors: Dr Sarah Doyle, Dr Catherine Duckett, Advisor: Dr Susan Campbell

Madalena de Oliveira, project entitled, The Impact of Vanishing White Matter mutations on eIF2B and mitochondrial function. Director of studies: Dr Liz Allen, Supervisors: Dr Susan Campbell, Dr Alison Cross.

Kate Garrard, project entitled, 'The Role of the Integrated Stress Response in Childhood Neurological Disease'. Director of studies: Dr Liz Allen, Supervisors: Dr Susan Campbell, Dr Santosh Mordekar.

Alex Knowles, project entitled,, Investigating Stress Responses during Periodontitis'. Director of studies: Dr Prachi Stafford, Supervisors: Dr Susan Campbell, Dr Neil Cross.

Filipe Hanson, project entitled, 'Investigating the role of the delta subunit of eIF2B during stress and disease' Director of Studies: Dr Susan Campbell, Supervisors: Dr Liz Allen, Dr Alison Cross.

Past PhD students:

Dr Rachel Hodgson, eIF2B bodies and their Role in the Integrated Stress Response'. Director of Studies: Dr Susan Campbell, Supervisors: Dr Liz Allen, Dr Caroline Dalton. Completed 2019

Dr Karl Norris, 'eIF2B bodies and their Role in the Control of Protein Synthesis' Director of studies, Dr Susan Campbell, Supervisors: Dr Ben Abell. Completed 2018

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Dr Susan Campbell B.A (Mod), PhD, FHEA

Summary

About

Teaching

Research

Publications

Journal articles

Conference papers

Book chapters

Theses / Dissertations

Media

Presentations

Posters

Other activities

Postgraduate supervision

Dr Susan Campbell B.A (Mod), PhD, FHEA

Summary

About

Teaching

Research

Publications

Journal articles

Conference papers

Book chapters

Theses / Dissertations

Media

Presentations

Posters

Other activities

Postgraduate supervision

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