Peter Strong

Professor Peter Strong MA, PhD, FRCS, CChem, FRSB, CBiol

Professor of Biomedical Sciences


Summary

Bristol University (BSc Chemistry)
University of Oregon (MA, PhD Organic Chemistry)
University of California (AMDA Postdoctoral Fellow)
University College London (Associate Research Fellow)
Imperial College (Senior Lecturer)
National University of Singapore (Visiting Professor)
Sheffield Hallam University (Professor of Biomedical Sciences).

Teaching

Biochemistry, Neuroscience and Pharmacology

BSc Biosciences Programme

MSc Biosciences Programme

Research

Antimicrobial venom peptides
Development of an ELISA for red scorpion venom antigenaemia
Mechamsim of action of chlorotoxin

Collaborators:

Dr Ekaterina Lyukmanova, Shemyakin Institute, Moscow, Russia
Professor A Chowdhary, Haffkine Institute, Mumbai, India
Professor K Jeyaseelan, National University of Singapore
Dr Mohamed Abdel Rahman, Suez Canal University, Egypt
Professor Steven Evans, Leeds University

Publications

Journal articles

Abdel-Rahman, M.A., Cao, Z., Abd El-Aziz, T.M., Strong, P., & Sabatier, J.-.M. (2024). Editorial: Structural and functional venomics as a powerful approach for drug discovery and development. Frontiers in Pharmacology, 15. http://doi.org/10.3389/fphar.2024.1405681

Rawson, K.M., Lacey, M.M., Strong, P.N., & Miller, K. (2022). Improving the therapeutic index of Smp24, a venom-derived antimicrobial peptide: increased activity against gram-negative bacteria. International Journal of Molecular Sciences, 23 (14). http://doi.org/10.3390/ijms23147979

Elrayess, R.A., Mohallal, M.E., Mobarak, Y.M., Ebaid, H.M., Haywood-Small, S., Miller, K., ... Abdel-Rahman, M.A. (2022). Scorpion Venom Antimicrobial Peptides Induce Caspase-1 Dependant Pyroptotic Cell Death. Frontiers in Pharmacology, 12. http://doi.org/10.3389/fphar.2021.788874

Elrayess, R.A., Mohallal, M.E., El-Shahat, Y.M., Ebaid, H.M., Miller, K., Strong, P., & Abdel-Rahman, M.A. (2019). Cytotoxic effects of Smp24 and Smp43 scorpion venom antimicrobial peptides on tumour and non-tumour cell lines. International Journal of Peptide Research and Therapeutics, 26 (3), 1409-1415. http://doi.org/10.1007/s10989-019-09932-1

Clark, G.C., Casewell, N.R., Elliott, C.T., Harvey, A.L., Jamieson, A.G., Strong, P., & Turner, A.D. (2019). Friends or Foes? Emerging Impacts of Biological Toxins. Trends in Biochemical Sciences, 44 (4), 365-379. http://doi.org/10.1016/j.tibs.2018.12.004

Heath, G.R., Harrison, P., Strong, P., Evans, S.D., & Miller, K. (2018). Visualization of diffusion limited antimicrobial peptide attack on supported lipid membranes. Soft Matter, 14 (29), 6146-6154. http://doi.org/10.1039/c8sm00707a

Harrison, P.L., Abdel-Rahman, M.A., Strong, P., Tawfik, M.M., & Miller, K. (2016). Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. Toxicon, 117, 30-36. http://doi.org/10.1016/j.toxicon.2016.03.014

Harrison, P.L., Heath, G.R., Johnson, B.R.G., Abdel-Rahman, M.A., Strong, P., Evans, S.D., & Miller, K. (2016). Phospholipid dependent mechanism of smp24, an α-helical antimicrobial peptide from scorpion venom. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1858 (11), 2737-2744. http://doi.org/10.1016/j.bbamem.2016.07.018

Abdel-Rahman, M.A., Harrison, P.L., & Strong, P. (2015). Snapshots of scorpion venomics. Journal of Arid Environments, 112 (Part B), 170-176. http://doi.org/10.1016/j.jaridenv.2014.01.007

Harrison, P.L., Abdel-Rahman, M., Miller, K., & Strong, P. (2014). Antimicrobial peptides from scorpion venoms. Toxicon, 88, 115-137. http://doi.org/10.1016/j.toxicon.2014.06.006

Abdel-Rahman, M.A., Abdel-Nabi, I.M., El-Naggar, M.S., Abbas, O.A., & Strong, P. (2013). Conus vexillum venom induces oxidative stress in Ehrlich's ascites carcinoma cells: an insight into the mechanism of induction. Journal of Venomous Animals and Toxins including Tropical Diseases, 19 (1), 10. http://doi.org/10.1186/1678-9199-19-10

Chai, S.C., Armugam, A., Strong, P.N., & Jeyaseelan, K. (2012). Charaterization of bumarsin, a 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitor from Mesobuthus martensii Karsch venom. Toxicon, 60 (3), 272-279. http://doi.org/10.1016/j.toxicon.2012.04.352

Kaur, P., Ghariwala, V., Yeo, K.S., Tan, H.Z., Tan, J.C.S., Armugam, A., ... Jeyaseelan, K. (2012). Biochemistry of envenomation. Current Advances in Clinical Chemistry, 57, 187-252. http://doi.org/10.1016/B978-0-12-394384-2.00007-3

Abdel-Rahman, M.A., Abdel-Nabi, I.M., El-Naggar, M.S., Abbas, O.A., & Strong, P. (2011). Intraspecific variation in the venom of the vermivorous cone snail Conus vexillum. Comparative Biochemistry and Physiology Toxicology Pharmacology, 154 (4), 318-325. http://doi.org/10.1016/j.cbpc.2011.06.019

Newton, K.A., Clench, M.R., Deshmukh, R., Jeyaseelan, K., & Strong, P.N. (2007). Mass fingerprinting of toxic fractions from the venom of the Indian red scorpion, mesobuthus tamulus: biotope-specific variation in the expression of venom peptides. Rapid communications in mass spectrometry, 21 (21), 3467-3476. http://doi.org/10.1002/rcm.3240

Pedarzani, P., D'hoedt, D., Doorty, K.B., Wadsworth, J.D.F., Joseph, J.S., Jeyaseelan, K., ... Strong, P. (2002). Tamapin, a venom peptide from the Indian red scorpion (mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons. Journal of Biological Chemistry, 277 (48), 46101-46109. http://doi.org/10.1074/jbc.M206465200

Montagna, P., Liguori, R., Monari, L., Strong, P.N., Riva, R., Di Stasi, V., ... Cipone, M. (2001). Equine muscular dystrophy with myotonia. Clinical neurophysiology, 112 (2), 294-299. http://doi.org/10.1016/S1388-2457(00)00511-3

Strong, P.N., Clark, G.S., Armugam, A., De-Allie, F.A., Joseph, J.S., Yemul, V., ... Jeyaseelan, K. (2000). Tamulustoxin: a novel potassium channel blocker from the venom of the Indian red scorpion mesobuthus tamulus. Archives of biochemistry and biophysics, 385 (1), 138-144. http://doi.org/10.1006/abbi.2000.2135

Book chapters

Strong, P.N., Mukherjee, S., Shah, N., Chowdhary, A., & Jeyaseelan, K. (2015). Scorpion venom research around the world: Indian Red Scorpion. In Gopalakrishnakone, P., Ferroni Schwartz, E., Possani, L.D., & Rodríguez de la Vega, R.C. (Eds.) Toxinology. Volume 4, Scorpion Venoms. (pp. 1-13). Netherlands: Springer: http://doi.org/10.1007/978-94-007-6647-1_5-1

Theses / Dissertations

Freeman-Parry, L.E. (2020). Antimicrobial properties of wound dressings. (Doctoral thesis). Supervised by Miller, K., & Strong, P. http://doi.org/10.7190/shu-thesis-00417

Elzayat, M.T. (2017). Characterisation of novel antimicrobial peptides from Egyptian scorpion and snake venoms. (Doctoral thesis). Supervised by Miller, K., & Strong, P.

Harrison, P.L. (2014). The identification and characterisation of antimicrobial peptides from snake and scorpion venom. (Doctoral thesis). Supervised by Miller, K., & Strong, P.

Newton, K.A. (2004). Biochemical studies on scorpion (Mesobuthus tamulus) and bee (Apis mellifera) venom peptides. (Doctoral thesis). Supervised by Strong, P.

Other activities

External examiner, Nottingham Trent University
Reviews Editor, Toxicon
STEM Ambassador

Postgraduate supervision

2015 - 2019 Kirstie Rawson - Antimicrobial peptides from venom: structure, function and toxicity

previous supervision:

Dr R El-Rayess

Dr M Tawfik

Dr P Harrison

Dr KA Newton

Dr KB Doorty

Dr FA De-Allie

Dr BS Brewster

Dr TG Sherratt

Dr A Clerk

Dr NA Castle

Dr NK Kotecha

Dr NS Cook



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