Professor Peter Strong MA, PhD, FRCS, CChem, FRSB, CBiol
Professor of Biomedical Sciences
Summary
Bristol University (BSc Chemistry)
University of Oregon (MA, PhD Organic Chemistry)
University of California (AMDA Postdoctoral Fellow)
University College London (Associate Research Fellow)
Imperial College (Senior Lecturer)
National University of Singapore (Visiting Professor)
Sheffield Hallam University (Professor of Biomedical Sciences).
Teaching
Biochemistry, Neuroscience and Pharmacology
BSc Biosciences Programme
MSc Biosciences Programme
Research
Antimicrobial venom peptides
Development of an ELISA for red scorpion venom antigenaemia
Mechamsim of action of chlorotoxin
Collaborators:
Dr Ekaterina Lyukmanova, Shemyakin Institute, Moscow, Russia
Professor A Chowdhary, Haffkine Institute, Mumbai, India
Professor K Jeyaseelan, National University of Singapore
Dr Mohamed Abdel Rahman, Suez Canal University, Egypt
Professor Steven Evans, Leeds University
Publications
Journal articles
Abdel-Rahman, M.A., Cao, Z., Abd El-Aziz, T.M., Strong, P., & Sabatier, J.-.M. (2024). Editorial: Structural and functional venomics as a powerful approach for drug discovery and development. Frontiers in Pharmacology, 15. http://doi.org/10.3389/fphar.2024.1405681
Rawson, K.M., Lacey, M.M., Strong, P.N., & Miller, K. (2022). Improving the therapeutic index of Smp24, a venom-derived antimicrobial peptide: increased activity against gram-negative bacteria. International Journal of Molecular Sciences, 23 (14). http://doi.org/10.3390/ijms23147979
Elrayess, R.A., Mohallal, M.E., Mobarak, Y.M., Ebaid, H.M., Haywood-Small, S., Miller, K., ... Abdel-Rahman, M.A. (2022). Scorpion Venom Antimicrobial Peptides Induce Caspase-1 Dependant Pyroptotic Cell Death. Frontiers in Pharmacology, 12. http://doi.org/10.3389/fphar.2021.788874
Elrayess, R.A., Mohallal, M.E., El-Shahat, Y.M., Ebaid, H.M., Miller, K., Strong, P., & Abdel-Rahman, M.A. (2019). Cytotoxic effects of Smp24 and Smp43 scorpion venom antimicrobial peptides on tumour and non-tumour cell lines. International Journal of Peptide Research and Therapeutics, 26 (3), 1409-1415. http://doi.org/10.1007/s10989-019-09932-1
Clark, G.C., Casewell, N.R., Elliott, C.T., Harvey, A.L., Jamieson, A.G., Strong, P., & Turner, A.D. (2019). Friends or Foes? Emerging Impacts of Biological Toxins. Trends in Biochemical Sciences, 44 (4), 365-379. http://doi.org/10.1016/j.tibs.2018.12.004
Heath, G.R., Harrison, P., Strong, P., Evans, S.D., & Miller, K. (2018). Visualization of diffusion limited antimicrobial peptide attack on supported lipid membranes. Soft Matter, 14 (29), 6146-6154. http://doi.org/10.1039/c8sm00707a
Harrison, P.L., Abdel-Rahman, M.A., Strong, P., Tawfik, M.M., & Miller, K. (2016). Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. Toxicon, 117, 30-36. http://doi.org/10.1016/j.toxicon.2016.03.014
Harrison, P.L., Heath, G.R., Johnson, B.R.G., Abdel-Rahman, M.A., Strong, P., Evans, S.D., & Miller, K. (2016). Phospholipid dependent mechanism of smp24, an α-helical antimicrobial peptide from scorpion venom. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1858 (11), 2737-2744. http://doi.org/10.1016/j.bbamem.2016.07.018
Abdel-Rahman, M.A., Harrison, P.L., & Strong, P. (2015). Snapshots of scorpion venomics. Journal of Arid Environments, 112 (Part B), 170-176. http://doi.org/10.1016/j.jaridenv.2014.01.007
Harrison, P.L., Abdel-Rahman, M., Miller, K., & Strong, P. (2014). Antimicrobial peptides from scorpion venoms. Toxicon, 88, 115-137. http://doi.org/10.1016/j.toxicon.2014.06.006
Abdel-Rahman, M.A., Abdel-Nabi, I.M., El-Naggar, M.S., Abbas, O.A., & Strong, P. (2013). Conus vexillum venom induces oxidative stress in Ehrlich's ascites carcinoma cells: an insight into the mechanism of induction. Journal of Venomous Animals and Toxins including Tropical Diseases, 19 (1), 10. http://doi.org/10.1186/1678-9199-19-10
Chai, S.C., Armugam, A., Strong, P.N., & Jeyaseelan, K. (2012). Charaterization of bumarsin, a 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitor from Mesobuthus martensii Karsch venom. Toxicon, 60 (3), 272-279. http://doi.org/10.1016/j.toxicon.2012.04.352
Kaur, P., Ghariwala, V., Yeo, K.S., Tan, H.Z., Tan, J.C.S., Armugam, A., ... Jeyaseelan, K. (2012). Biochemistry of envenomation. Current Advances in Clinical Chemistry, 57, 187-252. http://doi.org/10.1016/B978-0-12-394384-2.00007-3
Abdel-Rahman, M.A., Abdel-Nabi, I.M., El-Naggar, M.S., Abbas, O.A., & Strong, P. (2011). Intraspecific variation in the venom of the vermivorous cone snail Conus vexillum. Comparative Biochemistry and Physiology Toxicology Pharmacology, 154 (4), 318-325. http://doi.org/10.1016/j.cbpc.2011.06.019
Newton, K.A., Clench, M.R., Deshmukh, R., Jeyaseelan, K., & Strong, P.N. (2007). Mass fingerprinting of toxic fractions from the venom of the Indian red scorpion, mesobuthus tamulus: biotope-specific variation in the expression of venom peptides. Rapid communications in mass spectrometry, 21 (21), 3467-3476. http://doi.org/10.1002/rcm.3240
Pedarzani, P., D'hoedt, D., Doorty, K.B., Wadsworth, J.D.F., Joseph, J.S., Jeyaseelan, K., ... Strong, P. (2002). Tamapin, a venom peptide from the Indian red scorpion (mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons. Journal of Biological Chemistry, 277 (48), 46101-46109. http://doi.org/10.1074/jbc.M206465200
Montagna, P., Liguori, R., Monari, L., Strong, P.N., Riva, R., Di Stasi, V., ... Cipone, M. (2001). Equine muscular dystrophy with myotonia. Clinical neurophysiology, 112 (2), 294-299. http://doi.org/10.1016/S1388-2457(00)00511-3
Strong, P.N., Clark, G.S., Armugam, A., De-Allie, F.A., Joseph, J.S., Yemul, V., ... Jeyaseelan, K. (2000). Tamulustoxin: a novel potassium channel blocker from the venom of the Indian red scorpion mesobuthus tamulus. Archives of biochemistry and biophysics, 385 (1), 138-144. http://doi.org/10.1006/abbi.2000.2135
Book chapters
Strong, P.N., Mukherjee, S., Shah, N., Chowdhary, A., & Jeyaseelan, K. (2015). Scorpion venom research around the world: Indian Red Scorpion. In Gopalakrishnakone, P., Ferroni Schwartz, E., Possani, L.D., & Rodríguez de la Vega, R.C. (Eds.) Toxinology. Volume 4, Scorpion Venoms. (pp. 1-13). Netherlands: Springer: http://doi.org/10.1007/978-94-007-6647-1_5-1
Theses / Dissertations
Freeman-Parry, L.E. (2020). Antimicrobial properties of wound dressings. (Doctoral thesis). Supervised by Miller, K., & Strong, P. http://doi.org/10.7190/shu-thesis-00417
Elzayat, M.T. (2017). Characterisation of novel antimicrobial peptides from Egyptian scorpion and snake venoms. (Doctoral thesis). Supervised by Miller, K., & Strong, P.
Harrison, P.L. (2014). The identification and characterisation of antimicrobial peptides from snake and scorpion venom. (Doctoral thesis). Supervised by Miller, K., & Strong, P.
Newton, K.A. (2004). Biochemical studies on scorpion (Mesobuthus tamulus) and bee (Apis mellifera) venom peptides. (Doctoral thesis). Supervised by Strong, P.
Other activities
External examiner, Nottingham Trent University
Reviews Editor, Toxicon
STEM Ambassador
Postgraduate supervision
2015 - 2019 Kirstie Rawson - Antimicrobial peptides from venom: structure, function and toxicity
previous supervision:
Dr R El-Rayess
Dr M Tawfik
Dr P Harrison
Dr KA Newton
Dr KB Doorty
Dr FA De-Allie
Dr BS Brewster
Dr TG Sherratt
Dr A Clerk
Dr NA Castle
Dr NK Kotecha
Dr NS Cook